What is self-sabotage? Self-sabotage is when your thoughts and behaviors are harmful, hindering, or unhelpful to personal interests, desires, development, and your God-given vision. It interferes with long-standing goals. Spiritual self-sabotage is similar; however, it relates directly to a person’s relationship with God and practices and behaviors that undermine spiritual growth. 2 Corinthians 10:5 – Casting down imaginations, and every high thing that exalteth itself against the knowledge of God, and bringing into captivity every thought to the obedience of Christ